{"id":4087,"date":"2026-04-24T09:00:00","date_gmt":"2026-04-24T09:00:00","guid":{"rendered":"https:\/\/rjbarrett.redirectme.net\/?p=4087"},"modified":"2026-04-24T09:00:00","modified_gmt":"2026-04-24T09:00:00","slug":"%e5%b9%b9%e7%b4%b0%e8%83%9e%e7%99%82%e6%b3%95%e3%81%af%e5%8c%bb%e7%99%82%e3%82%92%e5%a4%89%e9%9d%a9%e3%81%97%e3%80%81%e8%80%81%e5%8c%96%e3%82%92%e9%80%86%e8%bb%a2%e3%81%95%e3%81%9b%e3%82%88%e3%81%86","status":"publish","type":"post","link":"https:\/\/rjbarrett.redirectme.net\/?p=4087","title":{"rendered":"\u5e79\u7d30\u80de\u7642\u6cd5\u306f\u533b\u7642\u3092\u5909\u9769\u3057\u3001\u8001\u5316\u3092\u9006\u8ee2\u3055\u305b\u3088\u3046\u3068\u3057\u3066\u3044\u308b\u306e\u3067\u3057\u3087\u3046\u304b?"},"content":{"rendered":"


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\u5e79\u7d30\u80de\u306f\u82e5\u8fd4\u308a\u6cbb\u7642\u306e\u305f\u3081\u306e\u90e8\u5206\u7684\u306a\u518d\u30d7\u30ed\u30b0\u30e9\u30df\u30f3\u30b0\u306e\u53ef\u80fd\u6027\u3092\u5b9f\u73fe\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b<\/p>\n

\u30ab\u30c6\u30ea\u30fc\u30ca\u30fb\u30b3\u30f3\/\u5199\u771f TECA CIENCIA\/Alamy<\/p>\n<\/div>\n<\/figcaption><\/figure>\n<\/p>\n

\u79c1\u306f\u9577\u5e74\u306b\u308f\u305f\u308a\u8001\u5316\u5206\u91ce\u3092\u53d6\u6750\u3057\u3066\u304a\u308a\u3001\u591a\u304f\u306e\u6709\u671b\u306a\u82e5\u8fd4\u308a\u7642\u6cd5\u304c\u8a87\u5927\u5ba3\u4f1d\u3055\u308c\u3066\u306f\u5931\u6557\u306b\u7d42\u308f\u308b\u306e\u3092\u898b\u3066\u304d\u307e\u3057\u305f\u3002\u3053\u306e\u7e70\u308a\u8fd4\u3055\u308c\u308b\u30b5\u30a4\u30af\u30eb\u306e\u30bc\u30ed\u70b9\u306f\u3001\u304b\u3064\u3066\u30d0\u30a4\u30aa\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u4f01\u696d\u30b5\u30fc\u30c8\u30ea\u30b9\u30fb\u30d5\u30a1\u30fc\u30de\u30b7\u30e5\u30fc\u30c6\u30a3\u30ab\u30eb\u30ba\u306b\u3088\u3063\u3066\u5947\u8de1\u306e\u8001\u5316\u9632\u6b62\u85ac\u3068\u3057\u3066\u5ba3\u4f1d\u3055\u308c\u305f\u5929\u7136\u5316\u5408\u7269\u3067\u3042\u308b\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\u3067\u3057\u305f\u3002 2008\u5e74\u3001\u88fd\u85ac\u5927\u624b\u30b0\u30e9\u30af\u30bd\u30fb\u30b9\u30df\u30b9\u30af\u30e9\u30a4\u30f3\u304c\u540c\u793e\u30927\u51042000\u4e07\u30c9\u30eb\u3067\u8cb7\u53ce\u3057\u305f\u304c\u3001\u305d\u306e\u5316\u5408\u7269\u304c\u5931\u6557\u306b\u7d42\u308f\u3063\u305f5\u5e74\u5f8c\u306b\u30b9\u30d4\u30f3\u30aa\u30d5\u3057\u305f\u3002\u540c\u69d8\u306e\u5931\u671b\u306f\u3001\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u3001\u8001\u5316\u306e\u30de\u30b9\u30bf\u30fc\u30b9\u30a4\u30c3\u30c1MTOR\u3092\u6a19\u7684\u3068\u3059\u308b\u85ac\u5264\u3001\u8001\u5316\u306e\u4e3b\u8981\u306a\u8981\u56e0\u3067\u3042\u308b\u30be\u30f3\u30d3\u7d30\u80de\u3092\u6392\u9664\u3059\u308b\u3088\u3046\u306b\u8a2d\u8a08\u3055\u308c\u305f\u8001\u5316\u7d30\u80de\u7834\u58ca\u7642\u6cd5\u3092\u60a9\u307e\u305b\u3066\u3044\u308b\u3002<\/p>\n

<\/p>\n

\u305d\u306e\u305f\u3081\u3001\u65b0\u3057\u3044\u7a2e\u985e\u306e\u82e5\u8fd4\u308a\u85ac\u306e\u6700\u521d\u306e\u81e8\u5e8a\u8a66\u9a13\u306b\u3064\u3044\u3066\u805e\u3044\u305f\u3068\u304d\u3001\u79c1\u306f\u3042\u307e\u308a\u8208\u596e\u3057\u306a\u3044\u3088\u3046\u306b\u52aa\u3081\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u898b\u308c\u3070\u898b\u308b\u307b\u3069\u3001\u4eca\u56de\u306f\u9055\u3046\u304b\u3082\u3057\u308c\u306a\u3044\u3068\u601d\u3044\u59cb\u3081\u307e\u3057\u305f\u3002 \u300c\u90e8\u5206\u7684\u306a\u30b9\u30b1\u30b8\u30e5\u30fc\u30eb\u5909\u66f4\u300d\u3092\u982d\u306e\u4e2d\u306b\u30e1\u30e2\u3057\u3066\u304a\u3044\u3066\u304f\u3060\u3055\u3044\u3002\u6700\u7d42\u7684\u306b\u8a87\u5927\u5ba3\u4f1d\u306b\u5fdc\u3048\u308b\u306e\u306f\u3001\u305d\u308c\u304b\u3082\u3057\u308c\u306a\u3044\u304b\u3089\u3067\u3059\u3002<\/p>\n

\u7269\u8a9e\u306f\u3001\u65e5\u672c\u306e\u4eac\u90fd\u5927\u5b66\u306e\u5c71\u4e2d\u4f38\u5f25\u6c0f\u304c\u96d1\u8a8c\u306b\u753b\u671f\u7684\u306a\u8ad6\u6587\u3092\u767a\u8868\u3057\u305f2006\u5e74\u306b\u59cb\u307e\u308a\u307e\u3059\u3002 \u7d30\u80de<\/em>\u3002\u5f7c\u3068\u540c\u50da\u306e\u9ad8\u6a4b\u548c\u654f\u6c0f\u306f\u3001\u6210\u719f\u3057\u305f\u76ae\u819a\u7d30\u80de\u306b\u305f\u3063\u305f4\u3064\u306e\u907a\u4f1d\u5b50\u3092\u52a0\u3048\u308b\u3060\u3051\u3067\u3001\u76ae\u819a\u7d30\u80de\u3092\u80ce\u5150\u306e\u72b6\u614b\u306b\u623b\u3059\u3053\u3068\u304c\u3067\u304d\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u305f\u3002\u3053\u308c\u306b\u3088\u308a\u7d30\u80de\u306b\u591a\u5206\u5316\u80fd\u304c\u4e0e\u3048\u3089\u308c\u3001\u3053\u308c\u306f\u307b\u307c\u3042\u3089\u3086\u308b\u7a2e\u985e\u306e\u7d30\u80de\u306b\u306a\u308b\u80fd\u529b\u3092\u53d6\u308a\u623b\u3057\u305f\u3053\u3068\u3092\u610f\u5473\u3057\u307e\u3059\u3002\u5f7c\u3089\u306f\u3053\u308c\u3089\u306e\u5947\u8de1\u306e\u7d30\u80de\u3092\u4eba\u5de5\u591a\u80fd\u6027\u5e79\u7d30\u80de (iPSC) \u3068\u547c\u3073\u3001\u3059\u3050\u306b\u751f\u7269\u79d1\u5b66\u3067\u6700\u3082\u30db\u30c3\u30c8\u306a\u30c1\u30b1\u30c3\u30c8\u306e 1 \u3064\u3068\u306a\u3063\u305f\u3082\u306e\u3092\u767a\u58f2\u3057\u307e\u3057\u305f\u3002<\/p>\n

iPSC \u306e\u6cbb\u7642\u53ef\u80fd\u6027\u306f\u3059\u3050\u306b\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u7d30\u80de\u306e\u640d\u50b7\u3084\u5909\u6027\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u75c5\u6c17\u306f\u3001\u304a\u305d\u3089\u304f\u4f55\u5343\u3082\u3042\u308a\u3001\u8001\u5316\u306b\u3088\u308b\u75c5\u6c17\u306e\u591a\u304f\u3082\u542b\u307e\u308c\u307e\u3059\u304c\u3001\u539f\u7406\u7684\u306b\u306f\u6cbb\u7652\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u4eba\u9593\u304b\u3089\u7d30\u80de\u3092\u63a1\u53d6\u3057\u3001\u305d\u3053\u304b\u3089 iPSC \u3092\u4f5c\u6210\u3057\u3001\u5fc3\u505c\u6b62\u306b\u3088\u3063\u3066\u640d\u50b7\u3057\u305f\u5fc3\u81d3\u3084\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306b\u3088\u3063\u3066\u7834\u58ca\u3055\u308c\u305f\u8133\u306a\u3069\u306e\u6a19\u7684\u81d3\u5668\u306b\u79fb\u690d\u3057\u307e\u3059\u3002 iPSC \u306f\u81ea\u7136\u306b\u5065\u5eb7\u306a\u65b0\u3057\u3044\u7d30\u80de\u306b\u5206\u5316\u3057\u3001\u640d\u50b7\u3092\u4fee\u5fa9\u3057\u307e\u3059\u3002\u3044\u308f\u3070\u82e5\u8fd4\u308a\u3002\u3055\u3089\u306b\u3001\u3053\u306e\u6280\u8853\u306f\u3001\u30af\u30ed\u30fc\u30f3\u4f5c\u6210\u3084\u80da\u306e\u7834\u58ca\u306a\u3069\u306e\u502b\u7406\u7684\u306b\u554f\u984c\u306e\u3042\u308b\u884c\u70ba\u3092\u884c\u308f\u305a\u306b\u5e79\u7d30\u80de\u3092\u4f9b\u7d66\u3067\u304d\u308b\u3053\u3068\u3092\u7d04\u675f\u3057\u307e\u3057\u305f\u3002<\/p>\n

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\u3053\u308c\u3089\u304a\u3088\u3073\u305d\u306e\u4ed6\u306e\u7406\u7531\u306b\u3088\u308a\u3001\u591a\u304f\u306e\u8a55\u8ad6\u5bb6\u306f iPSC \u306e\u6cbb\u7642\u53ef\u80fd\u6027\u3092\u5426\u5b9a\u3057\u3066\u3044\u307e\u3059 (\u305f\u3060\u3057\u3001\u305d\u306e\u79d1\u5b66\u7684\u4fa1\u5024\u306b\u7591\u554f\u306e\u4f59\u5730\u306f\u4e00\u5ea6\u3082\u3042\u308a\u307e\u305b\u3093\u3002\u5c71\u4e2d\u6c0f\u306f\u305d\u306e\u767a\u898b\u306b\u3088\u308a 2012 \u5e74\u306b\u30ce\u30fc\u30d9\u30eb\u8cde\u3092\u5171\u540c\u53d7\u8cde\u3057\u307e\u3057\u305f)\u3002 2008\u5e74\u3001\u30ab\u30ea\u30d5\u30a9\u30eb\u30cb\u30a2\u306e\u30d0\u30a4\u30aa\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u4f01\u696d\u30b8\u30a7\u30ed\u30f3\u793e\u306e\u793e\u9577\u30c8\u30e0\u30fb\u30aa\u30ab\u30de\u6c0f\u306f\u3053\u3046\u8a9e\u3063\u305f\u3002 \u65b0\u3057\u3044\u79d1\u5b66\u8005<\/em>: \u300c\u3053\u308c\u3089\u306f\u3001\u305b\u3044\u305c\u3044\u3001\u81ea\u7136\u306e\u4ee3\u7528\u3067\u3059\u3002\u300d [embryonic stem cells]\u3002\u305d\u308c\u3089\u306f\u6c7a\u3057\u3066\u4f7f\u7528\u3067\u304d\u307e\u305b\u3093…\u6280\u8853\u7684\u306b\u5b9f\u73fe\u4e0d\u53ef\u80fd\u3067\u3042\u308a\u3001\u9014\u65b9\u3082\u306a\u304f\u9ad8\u4fa1\u3067\u3059\u3002\u300d<\/p>\n

\u3057\u304b\u3057\u3001\u969c\u5bb3\u306f\u4e00\u3064\u305a\u3064\u30af\u30ea\u30a2\u3055\u308c\u3066\u3044\u304d\u307e\u3057\u305f\u3002\u5c71\u4e2d\u6c0f\u81ea\u8eab\u306f\u3001\u3053\u306e\u6280\u8853\u304c\u30d2\u30c8\u306e\u7d30\u80de\u3067\u6a5f\u80fd\u3059\u308b\u3053\u3068\u3001\u307e\u305f\u3001c-Myc \u304c\u306a\u304f\u3066\u3082\u591a\u80fd\u6027\u3092\u8a98\u5c0e\u3067\u304d\u308b\u3053\u3068\u3092\u5b9f\u8a3c\u3057\u305f\u3002\u4ed6\u306e\u30c1\u30fc\u30e0\u306f\u3001\u30ec\u30c8\u30ed\u30a6\u30a4\u30eb\u30b9\u3092\u4f7f\u308f\u305a\u306b\u3001\u4ee3\u308f\u308a\u306b\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\u3092\u4f7f\u7528\u3057\u3066\u907a\u4f1d\u5b50\u3092\u7d30\u80de\u306b\u5c0e\u5165\u3059\u308b\u65b9\u6cd5\u3092\u8003\u6848\u3057\u307e\u3057\u305f\u3002 2016 \u5e74\u306b\u3001\u90e8\u5206\u7684\u306a\u30b9\u30b1\u30b8\u30e5\u30fc\u30eb\u5909\u66f4\u3068\u3044\u3046\u65b0\u3057\u3044\u6982\u5ff5\u304c\u767b\u5834\u3057\u307e\u3057\u305f\u3002\u907a\u4f1d\u5b50\u3092\u633f\u5165\u3057\u3066\u6d3b\u6027\u72b6\u614b\u3092\u7dad\u6301\u3057\u3001\u3057\u305f\u304c\u3063\u3066\u6f5c\u5728\u7684\u306b\u5371\u967a\u306a\u72b6\u614b\u306b\u3059\u308b\u4ee3\u308f\u308a\u306b\u3001\u3057\u3070\u3089\u304f\u306e\u9593\u907a\u4f1d\u5b50\u3092\u30aa\u30f3\u306b\u3057\u3066\u304b\u3089\u30aa\u30d5\u306b\u3057\u3066\u306f\u3069\u3046\u3067\u3057\u3087\u3046\u304b?\u305d\u308c\u3068\u3082\u30aa\u30f3\u3068\u30aa\u30d5\u3092\u7e70\u308a\u8fd4\u3057\u307e\u3059\u304b?\u3053\u308c\u306b\u3088\u308a\u3001\u7d30\u80de\u304c\u591a\u5206\u5316\u80fd\u3078\u306e\u9053\u306e\u4e00\u90e8\u3068\u3057\u3066\u9000\u884c\u3057\u3001\u7d30\u80de\u304c\u767a\u75c7\u3059\u308b\u30ea\u30b9\u30af\u3092\u8efd\u6e1b\u3057\u306a\u304c\u3089\u82e5\u8fd4\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u308c\u306f\u3046\u307e\u304f\u3044\u304d\u307e\u3057\u305f<\/p>\n

\n
\"\"<\/div>
\n
\n

\u7dd1\u5185\u969c\u306f\u76ee\u306e\u8996\u795e\u7d4c\u3092\u640d\u50b7\u3057\u307e\u3059<\/p>\n

\u30b9\u30bf\u30f3\u30d5\u30a9\u30fc\u30c9\u5927\u5b66\/\u79d1\u5b66\u53f2\u753b\u50cf\/Alamy<\/p>\n<\/div>\n<\/figcaption><\/figure>\n<\/p>\n

\u3053\u3053\u3067\u81e8\u5e8a\u8a66\u9a13\u306e\u8a71\u306b\u623b\u308a\u307e\u3059\u304c\u3001\u521d\u3081\u3066\u90e8\u5206\u7684\u306a\u518d\u30d7\u30ed\u30b0\u30e9\u30df\u30f3\u30b0\u304c\u4eba\u4f53\u3067\u30c6\u30b9\u30c8\u3055\u308c\u307e\u3057\u305f\u3002\u5bfe\u8c61\u3068\u306a\u308b\u306e\u306f\u3001\u52a0\u9f62\u306b\u4f34\u3046\u773c\u306e\u5909\u6027\u75be\u60a3\u3067\u3042\u308b\u7dd1\u5185\u969c\u3068\u3001\u975e\u52d5\u8108\u708e\u6027\u524d\u90e8\u865a\u8840\u6027\u8996\u795e\u7d4c\u969c\u5bb3\uff08NAION\uff09\u3068\u547c\u3070\u308c\u308b\u540c\u69d8\u306e\u75be\u60a3\u3067\u3042\u308b\u3002<\/p>\n

18\u4eba\u306e\u53c2\u52a0\u8005\uff0812\u4eba\u304c\u7dd1\u5185\u969c\u30016\u4eba\u304cNAION\u60a3\u8005\uff09\u306f\u3001\u5c71\u4e2d\u56e0\u5b50\u304b\u3089c-Myc\u3092\u9664\u3044\u305f\u975e\u611f\u67d3\u6027\u30a6\u30a4\u30eb\u30b9\u3092\u305d\u308c\u305e\u308c\u5358\u773c\u6ce8\u5c04\u3055\u308c\u308b\u3002\u3053\u308c\u3089\u306f\u3001\u7d4c\u53e3\u85ac\u3092\u4f7f\u7528\u3057\u3066 56 \u65e5\u9593\u6d3b\u6027\u5316\u3055\u308c\u3001\u305d\u306e\u5f8c\u30aa\u30d5\u306b\u306a\u308a\u307e\u3059\u3002\u3053\u308c\u306f\u7b2c I \u76f8\u8a66\u9a13\u3067\u3042\u308b\u305f\u3081\u3001\u76ee\u7684\u306f\u6cbb\u7642\u304c\u5b89\u5168\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3059\u3053\u3068\u3067\u3059\u3002\u305d\u3046\u3067\u3042\u308c\u3070\u3001\u6cbb\u9a13\u306f\u30d5\u30a7\u30fc\u30ba II \u306b\u9032\u307f\u3001\u5909\u6027\u304c\u6b62\u307e\u308b\u304b\u9006\u8ee2\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u78ba\u8a8d\u3057\u307e\u3059\u3002\u3082\u3057\u305d\u3046\u306a\u3089\u3001\u305d\u308c\u306f\u4f55\u5e74\u3082\u5206\u304b\u3089\u306a\u3044\u3053\u3068\u3060\u304c\u3001\u3053\u306e\u85ac\u3092\u958b\u767a\u3057\u305f\u30de\u30b5\u30c1\u30e5\u30fc\u30bb\u30c3\u30c4\u5dde\u306e\u30e9\u30a4\u30d5\u30fb\u30d0\u30a4\u30aa\u30b5\u30a4\u30a8\u30f3\u30b7\u30ba\u793e\u306f\u3001\u4ed6\u306e\u591a\u304f\u306e\u75c5\u6c17\u3092\u7814\u7a76\u3059\u308b\u3064\u3082\u308a\u3067\u3042\u308b\u3002\u4ed6\u306e\u591a\u304f\u306e\u4f01\u696d\u3082\u90e8\u5206\u7684\u306a\u30b9\u30b1\u30b8\u30e5\u30fc\u30eb\u5909\u66f4\u30b2\u30fc\u30e0\u306b\u53c2\u52a0\u3057\u3066\u3044\u308b\u3002<\/p>\n

\u3060\u304b\u3089\u3053\u306e\u7a7a\u9593\u3092\u898b\u3066\u304f\u3060\u3055\u3044\u3002\u90e8\u5206\u7684\u306a\u30b9\u30b1\u30b8\u30e5\u30fc\u30eb\u306e\u5909\u66f4\u306f\u3001\u6b21\u306b\u8d77\u3053\u308b\u5927\u304d\u306a\u5931\u6557\u3092\u5f85\u3063\u3066\u3044\u308b\u3060\u3051\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u3001\u305d\u308c\u304c\u6210\u529f\u3059\u308c\u3070\u3001\u79c1\u305f\u3061\u306f\u65b0\u3057\u3044\u4e16\u754c\u306b\u5165\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u5f53\u6642\u82f1\u56fd\u30ea\u30d0\u30d7\u30fc\u30eb\u5927\u5b66\u8001\u5316\u30fb\u6162\u6027\u75be\u60a3\u7814\u7a76\u6240\u306e\u30b8\u30e7\u30a2\u30f3\u30fb\u30da\u30c9\u30ed\u30fb\u30c7\u30fb\u30de\u30ac\u30ea\u30e3\u30a8\u30b9\u6c0f\u306f2019\u5e74\u306b\u79c1\u306b\u3053\u3046\u8a9e\u3063\u305f\u3002\u300c\u8001\u5316\u306e\u6291\u5236\u304c\u533b\u7642\u3068\u793e\u4f1a\u306b\u591a\u5927\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u3092\u8003\u3048\u308b\u3068\u3001\u305f\u3063\u305f1\u793e\u3067\u3082\u6210\u529f\u3059\u308c\u3070\u3001\u305d\u308c\u306f\u5909\u9769\u7684\u306a\u3053\u3068\u306b\u306a\u308b\u3060\u308d\u3046\u3002\u300d<\/p>\n

\n

\u30c8\u30d4\u30c3\u30af:<\/p>\n<\/section><\/div>\n\n","protected":false},"excerpt":{"rendered":"

\u5e79\u7d30\u80de\u306f\u82e5\u8fd4\u308a\u6cbb\u7642\u306e\u305f\u3081\u306e\u90e8\u5206\u7684\u306a\u518d\u30d7\u30ed\u30b0\u30e9\u30df\u30f3\u30b0\u306e\u53ef\u80fd\u6027\u3092\u5b9f\u73fe\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b \u30ab\u30c6\u30ea\u30fc\u30ca\u30fb\u30b3\u30f3\/\u5199\u771f TECA CIENCIA\/Alamy 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