{"id":4255,"date":"2026-05-07T21:19:00","date_gmt":"2026-05-07T21:19:00","guid":{"rendered":"https:\/\/rjbarrett.redirectme.net\/?p=4255"},"modified":"2026-05-07T21:19:00","modified_gmt":"2026-05-07T21:19:00","slug":"%e3%83%8b%e3%83%b3%e3%83%8b%e3%82%af%e5%8c%96%e5%90%88%e7%89%a9%e3%81%af%e7%ad%8b%e8%82%89%e3%81%ae%e8%80%81%e5%8c%96%e3%82%92%e9%81%85%e3%82%89%e3%81%9b%e3%82%8b%e6%89%8b%e3%81%8c%e3%81%8b%e3%82%8a","status":"publish","type":"post","link":"https:\/\/rjbarrett.redirectme.net\/?p=4255","title":{"rendered":"\u30cb\u30f3\u30cb\u30af\u5316\u5408\u7269\u306f\u7b4b\u8089\u306e\u8001\u5316\u3092\u9045\u3089\u305b\u308b\u624b\u304c\u304b\u308a\u304c\u3042\u308b\u304b\u3082\u3057\u308c\u306a\u3044 |\u79d1\u5b66\u30cb\u30e5\u30fc\u30b9"},"content":{"rendered":"


\n<\/p>\n

\n

\u65e5\u672c\u306e\u7814\u7a76\u8005\u3089\u306f\u3001\u719f\u6210\u30cb\u30f3\u30cb\u30af\u62bd\u51fa\u7269\u306b\u542b\u307e\u308c\u308b\u5206\u5b50\u3067\u3042\u308bS-1-\u30d7\u30ed\u30da\u30cb\u30eb-L-\u30b7\u30b9\u30c6\u30a4\u30f3\u304c\u3001\u65b0\u305f\u306b\u540c\u5b9a\u3055\u308c\u305f\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3067\u9ad8\u9f62\u30de\u30a6\u30b9\u306e\u4f53\u529b\u3092\u56de\u5fa9\u3057\u3001\u865a\u5f31\u6027\u3092\u8efd\u6e1b\u3057\u305f\u3068\u8ff0\u3079\u3066\u3044\u308b\u3002<\/strong><\/p>\n

\"\u9234\u6728\u3089\u3002\u719f\u6210\u30cb\u30f3\u30cb\u30af\u62bd\u51fa\u7269\u7531\u6765\u306e\u751f\u7406\u6d3b\u6027\u5316\u5408\u7269\u3067\u3042\u308bS1PC\u304c\u9ad8\u9f62\u30de\u30a6\u30b9\u306e\u7b4b\u6a5f\u80fd\u3092\u6539\u5584\u3057\u3001\u9ad8\u9f62\u8005\u306e\u865a\u5f31\u3068\u95d8\u3046\u305f\u3081\u306e\u4f4e\u30b3\u30b9\u30c8\u6226\u7565\u3092\u6307\u3057\u793a\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u5831\u544a\u3057\u3066\u3044\u308b\u3002\u753b\u50cf\u30af\u30ec\u30b8\u30c3\u30c8:<\/p>\n

\u9234\u6728 \u4ed6<\/em>\u3002\u719f\u6210\u30cb\u30f3\u30cb\u30af\u62bd\u51fa\u7269\u7531\u6765\u306e\u751f\u7406\u6d3b\u6027\u5316\u5408\u7269\u3067\u3042\u308bS1PC\u304c\u9ad8\u9f62\u30de\u30a6\u30b9\u306e\u7b4b\u6a5f\u80fd\u3092\u6539\u5584\u3057\u3001\u9ad8\u9f62\u8005\u306e\u865a\u5f31\u3068\u95d8\u3046\u305f\u3081\u306e\u4f4e\u30b3\u30b9\u30c8\u6226\u7565\u3092\u6307\u3057\u793a\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u5831\u544a\u3057\u3066\u3044\u308b\u3002\u753b\u50cf\u63d0\u4f9b\uff1a\u9234\u6728 \u4ed6<\/em>.\u3001\u571f\u4e95: 10.1016\/j.cmet.2026.04.006\u3002<\/p>\n<\/div>\n

\u6b74\u53f2\u7684\u306b\u30cb\u30f3\u30cb\u30af\uff08\u30a2\u30ea\u30a6\u30e0\u30fb\u30b5\u30c6\u30a3\u30d0\u30e0<\/em>\uff09\u306f\u3001\u4e16\u754c\u4e2d\u3067\u5065\u5eb7\u4e0a\u306e\u554f\u984c\u3084\u75c5\u6c17\u306e\u6cbb\u7642\u306b\u5e83\u304f\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u53e4\u4ee3\u30a8\u30b8\u30d7\u30c8\u3001\u30ae\u30ea\u30b7\u30e3\u3001\u4e2d\u56fd\u3001\u30a4\u30f3\u30c9\u3067\u306f\u3001\u6d3b\u529b\u3092\u9ad8\u3081\u3001\u30b9\u30bf\u30df\u30ca\u3092\u5411\u4e0a\u3055\u305b\u3001\u611f\u67d3\u75c7\u3068\u6226\u3046\u305f\u3081\u306e\u4e07\u80fd\u85ac\u3068\u3057\u3066\u4f7f\u7528\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n

\u30cb\u30f3\u30cb\u30af\u81ea\u4f53\u3068\u719f\u6210\u30cb\u30f3\u30cb\u30af\u62bd\u51fa\u7269\uff08AGE\uff09\u304c\u4eba\u9593\u306b\u91cd\u8981\u306a\u5065\u5eb7\u4e0a\u306e\u5229\u70b9\u3092\u3082\u305f\u3089\u3059\u3053\u3068\u3092\u8a3c\u660e\u3059\u308b\u4e00\u9023\u306e\u79d1\u5b66\u7684\u8a3c\u62e0\u304c\u5897\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u30cb\u30f3\u30cb\u30af\u306e\u30a2\u30ea\u30b7\u30f3\u3001AGEs \u306e S-\u30a2\u30ea\u30eb-L-\u30b7\u30b9\u30c6\u30a4\u30f3 (SAC) \u304a\u3088\u3073 S-1-\u30d7\u30ed\u30da\u30cb\u30eb-L-\u30b7\u30b9\u30c6\u30a4\u30f3 (S1PC) \u306a\u3069\u3001\u591a\u304f\u306e\u751f\u7406\u6d3b\u6027\u6210\u5206\u304c\u7279\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u4e2d\u3067\u3082\u3001AGEs \u306b\u6bd4\u8f03\u7684\u591a\u304f\u542b\u307e\u308c\u308b\u542b\u786b\u30a2\u30df\u30ce\u9178\u3067\u3042\u308b S1PC \u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u306e\u6539\u5584\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u306e\u6539\u5584\u3001\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u4fdd\u8b77\u306a\u3069\u3001\u3055\u307e\u3056\u307e\u306a\u8208\u5473\u6df1\u3044\u85ac\u7406\u4f5c\u7528\u3092\u793a\u3057\u3001\u6700\u8fd1\u76db\u3093\u306b\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u300c\u7406\u5b66\u7642\u6cd5\u58eb\u3068\u3057\u3066\u306e\u81e8\u5e8a\u7d4c\u9a13\u306e\u4e2d\u3067\u3001\u6cbb\u7642\u304c\u5fc5\u8981\u306a\u7279\u5b9a\u306e\u75c5\u6c17\u304c\u306a\u3044\u3068\u3044\u3046\u3060\u3051\u306e\u7406\u7531\u3067\u9ad8\u9f62\u8005\u304c\u8eab\u4f53\u6a5f\u80fd\u3084\u6d3b\u529b\u3092\u5931\u3063\u3066\u3044\u304f\u306e\u3092\u898b\u3066\u30a4\u30e9\u30a4\u30e9\u3059\u308b\u3053\u3068\u304c\u3088\u304f\u3042\u308a\u307e\u3057\u305f\u3002\u7a4d\u6975\u7684\u306a\u30b1\u30a2\u306b\u304a\u3051\u308b\u3053\u306e\u30ae\u30e3\u30c3\u30d7\u304c\u79c1\u306e\u7814\u7a76\u306e\u539f\u52d5\u529b\u3068\u306a\u3063\u305f\u306e\u3067\u3059\u300d\u3068\u3001\u751f\u7523\u7684\u9ad8\u9f62\u5316\u7814\u7a76\u6240\u304a\u3088\u3073\u56fd\u7acb\u9577\u5bff\u533b\u7642\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u7814\u7a76\u54e1\u306e\u5409\u5ca1\u6f54\u535a\u58eb\u306f\u8ff0\u3079\u305f\u3002<\/p>\n

\u300c\u79c1\u305f\u3061\u306e\u7814\u7a76\u7d50\u679c\u304c\u3001\u6bce\u65e5\u306e\u98df\u4e8b\u306e\u4e00\u90e8\u3068\u3057\u3066\u6804\u990a\u88dc\u52a9\u98df\u54c1\u3092\u53d6\u308a\u5165\u308c\u308b\u3060\u3051\u3067\u3001\u9ad8\u9f62\u8005\u306e\u4f53\u529b\u3068\u7b4b\u529b\u3092\u5411\u4e0a\u3055\u305b\u308b\u306e\u306b\u5f79\u7acb\u3064\u3053\u3068\u3092\u9858\u3063\u3066\u3044\u307e\u3059\u3002\u300d<\/p>\n

\u3053\u306e\u7814\u7a76\u3067\u3001\u5409\u5ca1\u535a\u58eb\u3089\u306f\u3001S1PC\u304c\u7d30\u80de\u4ee3\u8b1d\u306e\u91cd\u8981\u306a\u8abf\u7bc0\u56e0\u5b50\u3067\u3042\u308b\u809d\u81d3\u30ad\u30ca\u30fc\u30bcB1\uff08LKB1\uff09\u9175\u7d20\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u305f\u3002<\/p>\n

\u91cd\u8981\u306a\u306e\u306f\u3001S1PC \u306f LKB1 \u304c\u95a2\u4e0e\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u8907\u5408\u4f53\u306e\u5f62\u6210\u3092\u4fc3\u9032\u3057\u3001\u3053\u308c\u306b\u3088\u308a\u8102\u80aa\u7d44\u7e54\u304b\u3089\u306e\u7d30\u80de\u5916 NAMPT (eNAMPT) \u306e\u5206\u6ccc\u3092\u4fc3\u9032\u3059\u308b SIRT1 \u7d4c\u8def\u306e\u6d3b\u6027\u5316\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002<\/p>\n

\u9175\u7d20 eNAMPT \u306f\u3001\u7d30\u80de\u4fdd\u8b77\u3001DNA \u4fee\u5fa9\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u751f\u7523\u306b\u95a2\u4e0e\u3059\u308b\u5fc5\u9808\u306e\u5c0f\u5206\u5b50\u3067\u3042\u308b NAD+ \u5408\u6210\u306e\u9375\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n

\u7b4b\u8089\u306b\u76f4\u63a5\u4f5c\u7528\u3059\u308b\u4ee3\u308f\u308a\u306b\u3001\u8102\u80aa\u7d44\u7e54\u304b\u3089\u653e\u51fa\u3055\u308c\u305f\u7d30\u80de\u5916\u5c0f\u80de\u5185\u306e eNAMPT (eNAMPT-EV) \u306f\u8840\u6d41\u3092\u901a\u3063\u3066\u79fb\u52d5\u3057\u3001\u8133\u306e\u4e3b\u8981\u306a\u8abf\u7bc0\u4e2d\u67a2\u3067\u3042\u308b\u8996\u5e8a\u4e0b\u90e8\u306b\u4f5c\u7528\u3057\u307e\u3059\u3002<\/p>\n

\u3053\u306e\u76f8\u4e92\u4f5c\u7528\u306f\u4ea4\u611f\u795e\u7d4c\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u5897\u52a0\u3068\u95a2\u9023\u3057\u3066\u304a\u308a\u3001\u7b4b\u8089\u6a5f\u80fd\u306e\u6539\u5584\u306b\u8ca2\u732e\u3057\u307e\u3059\u3002<\/p>\n

\u3053\u306e\u7814\u7a76\u7d50\u679c\u306f\u3001\u8102\u80aa\u7d44\u7e54\u3001\u8133\u3001\u9aa8\u683c\u7b4b\u3092\u3064\u306a\u3050\u65b0\u3057\u3044\u4f1d\u9054\u7d4c\u8def\u3092\u660e\u3089\u304b\u306b\u3057\u3001\u52a0\u9f62\u306b\u4f34\u3046\u6a5f\u80fd\u4f4e\u4e0b\u3092\u3069\u306e\u3088\u3046\u306b\u8abf\u7bc0\u3067\u304d\u308b\u304b\u306b\u3064\u3044\u3066\u65b0\u305f\u306a\u6d1e\u5bdf\u3092\u63d0\u4f9b\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002<\/p>\n

S1PC \u306e\u6a5f\u80fd\u7684\u5229\u70b9\u306f\u3001\u9ad8\u9f62\u30de\u30a6\u30b9\u3067\u3055\u3089\u306b\u8a55\u4fa1\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

S1PC \u306e\u9577\u671f\u6295\u4e0e\u306b\u3088\u308a\u3001\u30d5\u30ec\u30a4\u30eb\u30b9\u30b3\u30a2\u304c\u6e1b\u5c11\u3057\u3001\u9aa8\u683c\u7b4b\u529b\u304c\u5897\u52a0\u3057\u3001\u6df1\u90e8\u4f53\u6e29\u304c\u56de\u5fa9\u3057\u307e\u3057\u305f\u3002<\/p>\n

\u6ce8\u76ee\u3059\u3079\u304d\u3053\u3068\u306b\u3001\u4eba\u4f53\u7814\u7a76\u3067\u306f\u3001\u7279\u306b\u5341\u5206\u306a\u8102\u80aa\u7d44\u7e54\u3092\u6709\u3059\u308b\u500b\u4eba\u306b\u304a\u3044\u3066\u3001S1PC \u304c\u5faa\u74b0 eNAMPT \u30ec\u30d9\u30eb\u3092\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

eNAMPT-EV\u5206\u6ccc\u306b\u5bfe\u3059\u308bS1PC\u306e\u660e\u78ba\u306a\u52b9\u679c\u304c\u7d30\u80de\u3001\u30de\u30a6\u30b9\u3001\u30d2\u30c8\u306e\u9593\u3067\u4fdd\u5b58\u3055\u308c\u3066\u3044\u308b\u3068\u3044\u3046\u767a\u898b\u306f\u3001\u30d2\u30c8\u306b\u304a\u3051\u308b\u6f5c\u5728\u7684\u306a\u8001\u5316\u9632\u6b62\u4ecb\u5165\u3068\u3057\u3066\u306eS1PC\u306e\u4f7f\u7528\u306b\u91cd\u5927\u306a\u610f\u5473\u3092\u6709\u3059\u308b\u3002<\/p>\n

\u300c\u79c1\u305f\u3061\u306e\u7814\u7a76\u7d50\u679c\u306f\u3001LKB1\u3092\u6d3b\u6027\u5316\u3057\u3001\u7b4b\u865a\u5f31\u3092\u6539\u5584\u3059\u308b\u81d3\u5668\u9593\u30b3\u30df\u30e5\u30cb\u30b1\u30fc\u30b7\u30e7\u30f3\u3092\u4fc3\u9032\u3059\u308b\u3068\u3044\u3046\u3001\u3053\u308c\u307e\u3067\u8a8d\u8b58\u3055\u308c\u3066\u3044\u306a\u304b\u3063\u305fS1PC\u306e\u30e6\u30cb\u30fc\u30af\u306a\u6a5f\u80fd\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u300d\u3068\u30d7\u30ed\u30c0\u30af\u30c6\u30a3\u30d6\u30fb\u30a8\u30a4\u30b8\u30f3\u30b0\u7814\u7a76\u6240\u6240\u9577\u306e\u4eca\u4e95\u614e\u4e00\u90ce\u535a\u58eb\u306f\u8ff0\u3079\u305f\u3002<\/p>\n

\u300cS1PC\u306b\u306f\u3001\u8a73\u7d30\u306a\u7814\u7a76\u306b\u5024\u3059\u308b\u5e83\u7bc4\u306a\u8001\u5316\u9632\u6b62\u52b9\u679c\u304c\u3042\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3068\u4e88\u6e2c\u3057\u3066\u3044\u307e\u3059\u3002\u300d<\/p>\n

\u7d50\u679c\u306f\u672c\u65e5\u96d1\u8a8c\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f \u7d30\u80de\u4ee3\u8b1d<\/em>\u3002<\/p>\n

_____<\/span><\/p>\n

\u9234\u6728\u6df3\u4e00\u90ce \u4ed6<\/em>\u3002\u30cb\u30f3\u30cb\u30af\u7531\u6765\u306e\u4ee3\u8b1d\u7269\u306f\u3001LKB1\u3092\u6d3b\u6027\u5316\u3057\u3001eNAMPT\u306e\u8102\u80aa\u5206\u6ccc\u3092\u4fc3\u9032\u3057\u3001\u8996\u5e8a\u4e0b\u90e8\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u4ecb\u3057\u3066\u52a0\u9f62\u306b\u4f34\u3046\u7b4b\u8089\u6a5f\u80fd\u3092\u6539\u5584\u3057\u307e\u3059\u3002 \u7d30\u80de\u4ee3\u8b1d<\/em>2026 \u5e74 5 \u6708 7 \u65e5\u306b\u30aa\u30f3\u30e9\u30a4\u30f3\u3067\u516c\u958b\u3002\u571f\u4e95: 10.1016\/j.cmet.2026.04.006<\/span><\/p>\n<\/p><\/div>\n\n","protected":false},"excerpt":{"rendered":"

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