DNA-guided CRISPR–Cas12a effectors for programmable RNA recognition and cleavage – Nature Biotechnology
Materials Acidaminococcus sp. Cas12a (AsCas12a) and Lachnospiraceae bacterium Cas12a (LbCas12a) were from Tolo Biotech. AsCas12a Ultra was from Integrated DNA Technologies, Inc. EnGen LbaCas12a and NEbuffer...
TxPert: using multiple knowledge graphs for prediction of transcriptomic perturbation effects – Nature Biotechnology
TxPert architecture TxPert predicts the transcriptional response \({\bf{y}}\in {\mathcal{Y}}\subset {{\mathbb{R}}}^{n}\) given a set of perturbation tokens \(P\subset {\mathcal{P}}:=\{1,\ldots ,N\}\) and a basal state representation derived from...